This release contains forward-looking statements within the meaning of, and made pursuant to the safe harbor provisions of, The Private Securities Litigation Reform Act of 1995. More information about the Company may be found on its website at Forward-Looking Statements BioSpecifics is developing XIAFLEX internally for human and canine lipomas. Asahi Kasei Pharma Corporation has development and commercial rights for XIAFLEX for Dupuytren’s contracture and Peyronie’s disease in Japan. XIAPEX is currently marketed in nine European and Eurasian markets: Austria, Denmark, Finland, Germany, Norway, Spain, Switzerland, Sweden, and the United Kingdom. is responsible for marketing XIAPEX ® for Dupuytren’s contracture in the 27 European Union member countries and 19 other European and Eurasian countries and also has commercialization and development rights for Peyronie’s disease in these same territories. for the treatment of Dupuytren's contracture in adults with palpable cord in the palm and is also developing XIAFLEX for the treatment of Peyronie's disease, which is currently in Phase 3 pivotal clinical trials, as well as for Frozen Shoulder (Adhesive Capsulitis) and cellulite. Its partner Auxilium Pharmaceuticals, Inc. is a biopharmaceutical company that has developed injectable collagenase for twelve clinical indications. Currently, there are no FDA approved pharmaceutical therapies for this disease.īioSpecifics Technologies Corp. Significant psychological distress is common among sexually active patients with Peyronie's disease. Peyronie's disease is characterized by the presence of inelastic collagen on the shaft of the penis, which can distort an erection and make sexual intercourse difficult or impossible in advanced cases. As the disease progresses, a cord is formed and the fingers may become progressively contracted. Actelion shares are traded on the SIX Swiss Exchange (ticker symbol: ATLN) as part of the Swiss blue-chip index SMI (Swiss Market Index SMI®).ĭupuytren’s contracture is caused by an abnormal accumulation of collagen in the palm of the hand characterized by the formation of nodules or lumps in the early stages. BioSpecifics will also receive royalties from net sales and payments on costs of goods sold in Actelion's territories from Auxilium, which will be a specified percentage of what Auxilium receives from Actelion.Īctelion is a Swiss biopharmaceutical company with $2.0B in 2011 worldwide sales in 2011 and over 2,500 employees focused on the discovery, development and marketing of innovative drugs for significant unmet medical needs. This lead pipeline indication has the potential to greatly increase the market for injectable collagenase due to the devastating effects of this disease.”īioSpecifics will receive a certain percentage of the $10 million upfront payment paid to Auxilium from Actelion as well as a certain percentage of the up to $16 million in potential regulatory, pricing and reimbursement milestone payments and $42.5 million in potential sales milestone payments. and nine European and Eurasian markets for patients with Dupuytren’s contracture and we look forward to potential additional approvals in these new partnership territories, as well as reporting top-line results from Auxilium’s global Phase III study of XIAFLEX for Peyronie’s disease by the end of the second quarter of this year. “XIAFLEX is already available in the U.S. “We are excited to announce this strategic collaboration with Actelion, which will further enable XIAFLEX to reach patients around the world who are in need of this treatment,” reflected Thomas L. Actelion will be primarily responsible for the applicable regulatory and commercialization activities for XIAFLEX in these countries. Under this agreement, Actelion will receive exclusive rights to commercialize XIAFLEX for the two indications in Canada, Australia, Brazil and Mexico upon receipt of the respective regulatory approvals. (Actelion) for the long-term development, supply and commercialization of XIAFLEX for the treatment of Dupuytren’s contracture and Peyronie’s disease. (Auxilium) has entered into a partnership with Actelion Pharmaceuticals Ltd. and XIAPEX ® in Europe and Eurasia, today announced that its partner Auxilium Pharmaceuticals, Inc. (NASDAQ: BSTC), a biopharmaceutical company developing first in class collagenase-based products marketed as XIAFLEX ® in the U.S. February 23, 2012) - BioSpecifics Technologies Corp. Company Overview Our Team Our Commitment Success Stories Upcoming Conferences CareersīioSpecifics Announces Partnership Between Auxilium and Actelion for XIAFLEX(R) in Canada, Australia, Brazil and Mexico.
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Bitwarden is among the best and safest solutions to store all of your logins and passwords while conveniently keeping them synced between all of your devices.īitwarden also features Bitwarden Send, which allows you to share text and files securely with end-to-end encryption. It aims to solve password management problems for individuals, teams, and business organizations. Bitwarden is a free and open-source password manager. Double Sided Incised (Engraved) Stone Tablet Fragment, with different engravings on both sides. This is a rare artifact from an early discovery of this site. This artifact was part of a 1920’s private collection found at Malaga Cove California, what is now known as archaeological site CA-LAN-138. These types of artifacts are known as “portable cosmos” which refer to the universe and are small enough to be carried versus large stone petroglyphs that are permanent structures. Artifact Info: The incredible archaeological interpretation of this rare artifact engravings are related to astrological events with additional interpretation that the Chumash used these objects to observe the solstices. Tagged: american, bennett, california, certified, charmstone, chumash, native, rare.Ĭertified Chumash Rare Engraved Stone Tablet, California Bennett COAĮxtremely Rare Double Sided Incised (Engraved) Chumash Stone Tablet Fragment. This item can be shipped to United States. The seller is “marieleff” and is located in Georgetown, Texas. This item is in the category “Collectibles\Cultures & Ethnicities\Native American\ US\Pre-1600\Artifacts”. The item “Certified Rare Chumash Native American Charmstone #2 California Bennett COA” is in sale since Saturday, October 19, 2019. This artifact has been in private collections. Britten Marin was the son of John Marin (original founder of Sports Illustrated Magazine). They are attributed to ceremonial context/purposes. T hey appear to have been used primarily for bringing rain and for successful fishing. Southern California Chumash Charmstones are rare. Location Found: Central/Southern California attributed to Chumash Culture. Statute covering cultural patrimony Code 2600, Chapter 14. Tagged: atl-atl, bennett, bernardino, california, certified, paleo, point, rare.Ĭertified Rare Chumash Native American Charmstone #2 California Bennett COA Certified Rare Chumash Charmstone #2. The item “Certified Rare Paleo Atl-Atl Point #1 San Bernardino Co California Bennett COA” is in sale since Friday, October 18, 2019. Location Found: San Bernardino County, California. Very significant from an archaeological perspective. Paleo Atl-Atl points are rare and this piece provides scientific evidence that ancient Paleo culture utilized the Atl-Atl weapon to launch dart points from a distance around 10,000 years ago. Tagged: american, bennett, california, certified, charmstone, chumash, native, rare.Ĭertified Rare Paleo Atl-Atl Point #1 San Bernardino Co California Bennett COAĬertified Rare Paleo Atl-Atl Dart Point #1 – California. The item “Certified Rare Chumash Native American Charmstone #2 California Bennett COA” is in sale since Sunday, December 29, 2019. They appear to have been used primarily for bringing rain and for successful fishing. Certified Rare Chumash Native American Charmstone #2 California Bennett COAĬertified Rare Chumash Charmstone #2. Scary Girl Voice ringtones in the Scary – Horror Ringtones category, quality ringtones 128kps, 320kps, no loss. 3D Surround Sound Ringtones 2.0 latest version APK Download by Ringtones Studio FM for Android free online at. Give your phone a professional feel with these studio recorded sounds Each talking ringtone is available in 3 different tones of voice, so youll be sure to find the perfect ringone for you. 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Proposed solutions to the problem of determining the number of shuffles required to randomize a deck of cards have drawn upon concepts from probability theory, statistics, combinatorial analysis, group theory, and communication theory. Introduction: The Card Randomization Problem Whereas mechanical shuffling resulted in significantly fewer rising sequencesġ. Number of manual shuffles matched very closely the theoretical predictionsīased on the Gilbert-Shannon-Reed (GSR) model of riffle shuffles, Number of shuffles and 4) the mean number of rising sequences as a function of Sensitive to different patterns indicative of residual order 2) as aĬonsequence, the threshold number of randomizing shuffles could vary widelyĪmong tests 3) in general, manual shuffling randomized a deck better than mechanical shuffling for a given Manually and by an auto-shuffling device were recorded sequentially andĪnalyzed in respect to 1) the theory of runs, 2) rank ordering, 3) serialĬorrelation, 4) theory of rising sequences, and 5) entropy and information theory.Īmong the outcomes, it was found that: 1) different statistical tests were Permutations of 52-cardĭecks, each subjected to sets of 19 successive riffle shuffles executed Randomizing shuffles, and 3) whether manual or mechanical shuffling randomizesĪ deck more effectively for a given number of shuffles. Whether different statistical tests yield different threshold numbers of Which of the two theoretical approaches made the more accurate prediction, 2) This paper reports a comprehensive experimentalĪnalysis of the card randomization problem for the purposes of determining 1) Which differed in how each defined randomness, has led to statistically different The two principal theoretical approaches to the problem, Please note that we may not be able to process the refund for your missing item if you lose or damage any packaging material.Question of how many shuffles are required to randomize an initially orderedĭeck of cards is a problem that has fascinated mathematicians, scientists, and *Please keep all contents of the original package including packaging material (boxes, plastic bags etc.) with you until you are instructed otherwise. *Contact our customer service center by phone or by forum (if you cannot reach us by phone) within 1 day of delivery. * Items with unsatisfactory/incomplete finish due to mass productionĤ) If there is a missing item from your order: * Items with creases that may have been made while shipping * Items that are originally manufactured without tags or labels The following items are not considered defective: your return request is not approved by our staff the products are damaged due to your mishandling you are returning shoes, bags, or any other accessories you are returning the items just because you changed your mind (on size, color, etc.) The shipping fee will be refunded once the returned item has arrived. However, if EMS’ cash on delivery is not possible then you can scan the return receipt and either mail it with the item to return or post an image of it on the forum. * Shipping fee for any return caused by our fault will be paid by the company. *Please include all contents of the original package and free gifts (if applicable) in your return packaging. The item(s) must be sent in their original packaging and unworn. *Please note that EVEN the defective/incorrect item(s) must be returned with all of the tags and labels intact. Returns that are shipped to us without any prior consent are not accepted. *Please be advised that returns are accepted ONLY IF you followed the instructions above and your return request has been approved by our staff. Also, you need to include a note of your order number, name, and user ID. (3) Items returned must be in their original condition, which includes tags and any packaging. (2) A customer service representative will be in contact to assist you by email or phone. You are required to attach the photos of the received product(s) and include the item code, the order number, and the reason for the return. (1) Post a return request on our Return forum within three days of receipt. you receive a product different from your order or the order is delayed for more than 10 days since payment and you have not received any notification regarding the delay or you posted a Return request within 24 hours of payment and your order is still under “Pending” status (if your order is under “Preparing Shipment” status, please contact our customer service center) or Refunds are issued once the returned products clear our inspection.ġ) An item is eligible for cancellation if: Please take into consideration that we only accept qualifying returns but not exchanges. "Just before Diddy Kong Racing, there was a month's worth of work on a strategy game that I did with Chris Stamper, but that was in the style of Command & Conquer and not related" “We’d just finished Killer Instinct II, and while some of the team went off to work on Killer Instinct Gold for the N64, we tried to start making a racing game”. “Right back at the beginning it was just me and Chris Stamper ”, Musgrave tells us. He gave us an insight into the game’s fascinating development, as well as what it was like to work at Rare during what many consider to be the studio’s golden era.įor a game that went on to sell an impressive number of copies, not to mention achieve near-universal critical acclaim, Diddy Kong Racing’s origins were remarkably humble. We caught up with Lee Musgrave, who worked as a 3D artist on Diddy Kong Racing and a number of other Rare titles before eventually going to become the studio’s Head of Art. When it was released in late 1997, it was a huge hit for a Rare. And in many ways, Diddy Kong Racing is most certainly the better game it added a host of new and engaging gameplay features while also offering much tighter controls. Fitting neatly into the kart racing genre, Diddy Kong Racing was the first real contender to challenge Nintendo’s dominance over the kart racing genre with Mario Kart 64. This game was not only huge for Diddy Kong’s street cred, but it was also a massive deal for Rare. Despite being a wholly new creation in 1994, Diddy Kong quickly became a popular Nintendo character, taking the lead role in 1995’s Donkey Kong Country 2: Diddy’s Kong Quest before finally getting a game to truly call his own in 1997: Diddy Kong Racing. One of the most noticeable ways in which it did this was by creating a host of new characters, the most notable of which was Diddy Kong. When developing the original Donkey Kong Country series, the gang at Rare not only worked hard to make great use of the franchise, but it also used it as an opportunity to leave its own mark. During the 1990s, the British development studio played a crucial role in not only keeping DK fresh and at the forefront of gamers’ minds, but also in shaping the entire future of the franchise Donkey Kong Country: Tropical Freeze, for example, is very clearly inspired by the impressive legacy that Rare created. Of course, no examination of Kong’s history would be complete without taking a closer look at Rare’s involvement with the franchise. Donkey Kong has had a long and vibrant history on the video game scene. La existencia de estos singulares armatostes, realizados con los materiales más diversos y precarios que se encuantran a al mano –cubetas rellanas de cemento, hierro, madera- ponen en manifiesto no sólo el terrible y complejo problema que vive la ciudad en su funcionalidad en cuanto a la falta de un efectivo y suficiente sistema de transporte público -se dice que más de 2 millones de autos atraviesan las calles de la Ciudad de México diariamente-, sino que evidencia también el enorme poder creativo de la población y su capacidad para resolver problemasn. No hay nada más terrible que el vacío de no permitirse haberlo intentado.Įsquemas para una oda tropical es una colección de estorbos robados y apropiados de las calles de las calles de la Ciudad de México a lo largo de varios años y unas réplicas de éstos elaborados con plantas.ĭesde el humor y la ironía, los estorbos crean en su conjunto una lectura de la situación cotidiana que lleva a los automovilistas a la desesperción, como resultado de la frustración por no poder encontrar un pequeño fragmento de la ciudad para estacionar sus aotomóviles. Para aquellos de nosotros que creemos, incluso hoy en día, que nuestro trabajo puede proponer o proyectar una mejor realidad, lo inmediato nos sirve no sólo de perfecto campo de prueba y experimentación sino de motivación y ejercicio necesario. Esquemas para una oda tropical, 2005, tecnica mixta con plantas y juego de 3 fotografías 38 x 41 cm c/u. This entry was posted in Uncategorized by Morgan Corley. I think the video brings this message along. What’s important is what’s inside of you, and you have to fight for that. So we’re trying to empower people to feel that it doesn’t matter if you’re different or if you’re from one country or the other or you’re black or you’re white or you’re gay. This reflects a whole cultural and social situation… We have lots of immigration issues in the states - that is, people coming from poorest countries to developed countries. She represents a whole community who are immigrants living in a foreign country, so she’s representing what’s happening in the world. On the performance by Gonzalez, who is of both Peruvian and Costa Rican descent She can be from everywhere in Latin America from Mexico to even Argentina she could be anyone. They showed us and we thought it was perfect because she represents a whole community. They did a very precise casting looking for this particular and special girl, and they came up with his girl. It was a whole process that the film crew did. On how they found Sarai Isaura Gonzalez, the 11-year-old actress in the video Sin embargo, en esta entrevista con NPR, la instrumentista Simon Mejia describe como la protagonista del video musical representa la comunidad entera de la diaspora latina en los Estados Unidos.Ī continuación se ofre ce n extractos de la entrevista con Simon Mejia. El video musical es una llamada para autoexpresión y envía un poderoso mensaje sobre el empoderamiento de mujeres-en particular el empoderamiento de mujeres y niñas morenas quien son ignoradas de la mayoría de la sociedad.Įl grupo Bomba Estéreo es de Columbia (no del Caribe). Por ejemplo, cuando dos niñas blancas juzgan su elección de moda, la protagonista aturden a sus escépticas a través de tocar ardientemente la flauta dulce. Su energía contagiosa y su confidencia rebosante rechaza las miradas raras que ella recibe. En el video musical de la canción “Soy Yo” de Bomba Estéreo, una niña morena se contonea por las calles de Nueva York. In case you face any issues, you can reach the customer support via multiple channels, including live chat, email, etc. In recent times, the company has introduced several new features, including the call recording button. As such, whether you’re using a laptop, a Mac, or a smartphone, you’ll be able to join or set up meetings, message colleagues, and use all the other features available within the application.Īdditionally, the program receives regular updates, which include new features and functionalities. For instance, you can download and install the program on Microsoft OS ( Windows 11, 10, 8,1), Android, iPad, iPod Touch, iPhone, and more. Since Microsoft Teams download runs on multiple operating systems, it allows you to stay connected with people via different devices. At times, the interface also looks formal and rigid. The only drawback is that the application lacks customization options. Backed by the IT giant, the tool saves a good amount of time spent in setting up conferences and meetings. The program also has a built-in search function, which lets you easily search content, files, documents, PDFs, and the application’s functionalities.Ĭompared to some other leading choices in this category, Microsoft Teams is faster, more responsive, and doesn’t cause any unexpected errors. Since the video conferencing app integrates with Microsoft Office 365 products, you can access data from Outlook, OneNote, and other services. The simple interface lets you conveniently open up conversations, attached files, multimedia content, and meeting invites. Moreover, you can directly import your contacts within the organization to make Microsoft Teams the central platform for official communication. This lets you access the meetings from your smartphone. It’s one of the most feature-packed collaboration tools available right now.Īs mentioned earlier, the app runs on multiple operating systems, including Android and iOS. Additionally, it comes with a range of features, including group chats, virtual meetups, audio calls, meeting recordings, transcripts, and more. Unlike other programs in this category, Microsoft Teams allows you to hold video conferences with up to 10,000 people simultaneously. In simple terms, the application functions as a digital hub, giving you multiple features to share files, indulge in chats, set up meetings, and perform collaborative tasks in real-time. The program lets you create a shared workspace, where you can collaborate with a good number of people. What happens when I delete or rename the database in Panoply?.Can I create Query Tables over the Panoply data?.Can I import data from other data sources into the same workspace that I have used to connect with Panoply?.Can I connect the new columns added in my Panoply database to Zoho Analytics?.Can I synchronize a data table from my Cloud Database instantly?.When do Mismatches occur and how to resolve them?.I got an alert message "This view cannot be accessed due to some changes made in the table" while accessing my tables/reports in Zoho Analytics.Can I link the related tables, connected from the Cloud Database using the Live Connect option, in Zoho Analytics?.Can I connect Views created in Panoply (apart from Tables) to Zoho Analytics?.Will the reports/dashboards query hit my database server every time I open it or can it be cached in Zoho Analytics?.How long does it take for me to visualize my data in Zoho Analytics?.How is Live Connect different from Data Import?.How do I connect live with the Panoply database?.The Last Data Sync Status in Datasources page shows Sync Failed.Can I synchronize the data from my Cloud Database instantly?.Can I import data from my Panoply database into an existing Zoho Analytics workspace?.Can I change the data source of this table? I have synced data from a database into a table. Can I import data from Panoply database table into an existing table in Zoho Analytics?.Can I add more tables from the same source to the existing connection? I have connected to a database and imported a few tables into Zoho Analytics.Can I change the data type of the columns in Zoho Analytics?.Will foreign keys defined between my tables in the Panoply database be linked in Zoho Analytics as well?.Can I import data from Views created in Panoply (apart from Tables) into Zoho Analytics?.How long does it take for the data to be imported into Zoho Analytics?.How do I import data from the Panoply database?.Refer to the Live Connect section to learn. Please note that the Live Connect option is exclusively available for paid plans and trials only. In this case the loading time will directly depend on the performance of Panoply. Instead for the reports that you create Zoho Analytics will generate appropriate queries that will connect the required data live from Panoply to Zoho Analytics and show you the report. Live Connect:In this mode, data will not be fetched from Panoply and stored in Zoho Analytics.Report loading time will be faster as the data is stored in Zoho Analytics. You can setup periodic schedules to fetch the latest data automatically from your Panoply database. Data Import:Data in Panoply will be imported and stored in Zoho Analytics.Zoho Analytics allows you to either import the data into Zoho Analytics or connect directly with the Panoply server. If you have your data stored in Panoply, then you can easily connect live/import the data into Zoho Analytics for advanced reporting and analysis. The second option to lower your payment is to increase the loan term. In real life, this means you would look for a less expensive car or pay more of a down payment. You could reduce the amount borrowed in the calculator. Is the payment too high? There are three ways you could lower your payment. It should be equal to the monthly loan term you typed in. This is how many payments you would make over the entire life of the loan. It should match the loan amount you typed in. This is how much money you would borrow in total. This is your estimated monthly payment based on what you typed in the fields we described above. Source: LendingTree data on closed auto loans by credit score on the LendingTree platform, H1 2022 View the resultsĮstimated auto payment. Here’s a table showing the APR you may qualify for based on your credit score. The actual amount you pay the lender is based on this percentage and how much you borrow. It’s what the lender charges for loaning you the money. We recommend getting a loan less than 84 months long. Most lenders use months instead of years for the term because the number of months is equal to the number of payments. This is how long the loan lasts from the time you sign the paperwork until the final monthly payment. If you have a trade-in, positive equity contributes to your down payment negative equity increases the amount you have to borrow. It should be the price of the car, minus any down payment, plus taxes and fees. We’ll explain the different parts of the calculator below. Adjust one number - how many months you’d like to pay, for example - and the monthly payment changes. The auto loan calculator takes the car price, loan term and loan APR, and uses that to tell you what your monthly payment would be. |
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